Cocktail polysaccharides isolated from Ecklonia kurome against the SARS-CoV-2 infection

Zhang S, pei R, Li M, Su H, Sun H, Ding Y, Su M, Huang C, Chen X, Du Z, Jin C, Zang Y, Li J, Xu Y, Chen X, Zhang B, Ding K.

Carbohydr polym.

published: 1 January 2022

DOI: https://doi.org/10.1016/j.carbpol.2021.118779


Serological investigation of asymptomatic cases of SARS-CoV-2 infection reveals weak and declining antibody responses

Yang Y, Wang X, Du RH, Zhang W, Si HR, Zhu Y, Shen XR, Li Q, Li B, Men D, Zhou YN, Wang H, Tong XL, Zhang XE, Shi ZL, Zhou p.

Emerg Microbes Infect.

published: December 2021

DOI: https://doi.org/10.1080/22221751.2021.1919032


The high diversity of SARS-CoV-2-related coronaviruses in pangolins alters potential ecological risks

peng MS, Li JB, Cai ZF, Liu H, Tang X, Ying R, Zhang JN, Tao JJ, Yin TT, Zhang T, Hu JY, Wu RN, Zhou ZY, Zhang ZG, Yu L, Yao YG, Shi ZL, Lu XM, Lu J, Zhang Yp.

Zool Res.

published: 18 November 2021

DOI: https://doi.org/10.24272/j.issn.2095-8137.2021.334


Comprehensive investigations revealed consistent pathophysiological alterations after vaccination with COVID-19 vaccines

Liu J, Wang J, Xu J, Xia H, Wang Y, Zhang C, Chen W, Zhang H, Liu Q, Zhu R, Shi Y, Shen Z, Xing Z, Gao W, Zhou L, Shao J, Shi J, Yang X, Deng Y, Wu L, Lin Q, Zheng C, Zhu W, Wang C, Sun YE, Liu Z.

Cell Discov.

published: 26 October 2021

DOI: https://doi.org/10.1038/s41421-021-00329-3

Intranasal delivery of replicating mRNA encoding neutralizing antibody against SARS-CoV-2 infection in mice

Li JQ, Zhang ZR, Zhang HQ, Zhang YN, Zeng XY, Zhang QY, Deng CL, Li XD, Zhang B, Ye HQ.

Signal Transduct Target Ther.

published: 25 October 2021

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Epidemiology of Viruses Causing pediatric Community Acquired pneumonia in Shanghai During 2010-2020: What Happened Before and After the COVID-19 Outbreak?

Li F, Zhang Y, Shi p, Cao L, Su L, Zhang Y, peng K, Lu R, Tan W, Shen J.

Infect Dis Ther.

published: 25 October 2021

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Design and development of an oral remdesivir derivative VV116 against SARS-CoV-2

Xie Y, Yin W, Zhang Y, Shang W, Wang Z, Luan X, Tian G, Aisa HA, Xu Y, Xiao G, Li J, Jiang H, Zhang S, Zhang L, Xu HE, Shen J.

Cell Res.

published: 28 September 2021

DOI: https://doi.org/10.1038/s41422-021-00570-1

Antibody-dependent cellular cytotoxicity response to SARS-CoV-2 in COVID-19 patients

Yu Y, Wang M, Zhang X, Li S, Lu Q, Zeng H, Hou H, Li H, Zhang M, Jiang F, Wu J, Ding R, Zhou Z, Liu M, Si W, Zhu T, Li H, Ma J, Gu Y, She G, Li X, Zhang Y, peng K, Huang W, Liu W, Wang Y.

Signal Transduct Target Ther.

published: 24 September 2021

DOI: https://doi.org/10.1038/s41392-021-00759-1

SARS-CoV-2 infection causes immunodeficiency in recovered patients by downregulating CD19 expression in B cells via enhancing B-cell metabolism

Jing Y, Luo L, Chen Y, Westerberg LS, Zhou p, Xu Z, Herrada AA, park CS, Kubo M, Mei H, Hu Y, Lee pp, Zheng B, Sui Z, Xiao W, Gong Q, Lu Z, Liu C.

Signal Transduct Target Ther.

published: 22 September 2021

DOI: https://doi.org/10.1038/s41392-021-00749-3


RBD-homodimer, a COVID-19 subunit vaccine candidate, elicits immunogenicity and protection in rodents and nonhuman primates

pan X, Shi J, Hu X, Wu Y, Zeng L, Yao Y, Shang W, Liu K, Gao G, Guo W, peng Y, Chen S, Gao X, peng C, Rao J, Zhao J, Gong C, Zhou H, Lu Y, Wang Z, Hu X, Cong W, Fang L, Yan Y, Zhang J, Xiong H, Yi J, Yuan Z, Zhou p, Shan C, Xiao G.

Cell Discov.

published: 7 September 2021

DOI: https://doi.org/10.1038/s41421-021-00320-y

Increased morbidity of obese mice infected with mouse-adapted SARS-CoV-2

Zhang YN, Zhang ZR, Zhang HQ, Li XD, Li JQ, Zhang QY, Liu J, Li Q, Deng CL, Shi ZL, Yuan ZM, Ye HQ, Zhang B.

Cell Discov.

published: 25 August 2021

DOI: https://doi.org/10.1038/s41421-021-00305-x

Systematic profiling of SARS-CoV-2-specific IgG responses elicited by an inactivated virus vaccine identifies peptides and proteins for predicting vaccination efficacy

Ma ML, Shi DW, Li Y, Hong W, Lai DY, Xue JB, Jiang HW, Zhang HN, Qi H, Meng QF, Guo SJ, Xia DJ, Hu JJ, Liu S, Li HY, Zhou J, Wang W, Yang X, Fan XL, Lei Q, Chen WJ, Li CS, Yang XM, Xu SH, Wei Hp, Tao SC.

Cell Discov.

published: 17 August 2021

DOI: https://doi.org/10.1038/s41421-021-00309-7

Decreased inhibition of exosomal miRNAs on SARS-CoV-2 replication underlies poor outcomes in elderly people and diabetic patients

Wang Y, Zhu X, Jiang XM, Guo J, Fu Z, Zhou Z, Yang p, Guo H, Guo X, Liang G, Zeng p, Xiao G, Ma J, Yin X, Zhang LK, Yan C, Zhang CY.

Signal Transduct Target Ther.

published: 11 August 2021

DOI: https://doi.org/10.1038/s41392-021-00716-y

Identification of potent human neutralizing antibodies against SARS-CoV-2 implications for development of therapeutics and prophylactics

Zhao S, Zhang H, Yang X, Zhang H, Chen Y, Zhan Y, Zhang X, Jiang R, Liu M, Liu L, Chen L, Tang W, peng C, Gao X, Zhang Z, Shi Z, Gong R.

Nat Commun.

published: 9 August 2021

DOI: https://doi.org/10.1038/s41467-021-25153-x

Discovery of potential small molecular SARS-CoV-2 entry blockers targeting the spike protein

Wang L, Wu Y, Yao S, Ge H, Zhu Y, Chen K, Chen WZ, Zhang Y, Zhu W, Wang HY, Guo Y, Ma pX, Ren pX, Zhang XL, Li HQ, Ali MA, Xu WQ, Jiang HL, Zhang LK, Zhu LL, Ye Y, Shang WJ, Bai F.

Acta pharmacol Sin.

published: 4 August 2021

DOI: https://doi.org/10.1038/s41401-021-00735-z

Direct Evidence of Active SARS-CoV-2 Replication in the Intestine

Qian Q, Fan L, Liu W, Li J, Yue J, Wang M, Ke X, Yin Y, Chen Q, Jiang C.

Clin Infect Dis.

published: 2 August 2021

DOI: https://doi.org/10.1093/cid/ciaa925

SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target

Xia B, Shen X, He Y, pan X, Liu FL, Wang Y, Yang F, Fang S, Wu Y, Duan Z, Zuo X, Xie Z, Jiang X, Xu L, Chi H, Li S, Meng Q, Zhou H, Zhou Y, Cheng X, Xin X, Jin L, Zhang HL, Yu DD, Li MH, Feng XL, Chen J, Jiang H, Xiao G, Zheng YT, Zhang LK, Shen J, Li J, Gao Z.

Cell Res.

published: August 2021

DOI: https://doi.org/10.1038/s41422-021-00519-4

From SARS, MERS to COVID-19: A journey to understand bat coronaviruses

Shi Z.

Bull Acad Natl Med.

published: August 2021

DOI: https://doi.org/10.1016/j.banm.2021.05.008

Safety and immunogenicity of an inactivated SARS-CoV-2 vaccine in healthy adults aged 18 years or older: A randomized, double-blind, placebo-controlled, phase 1/2 trial

Guo W, Duan K, Zhang Y, Yuan Z, Zhang YB, Wang Z, Zhao D, Zhang H, Xie Z, Li X, peng C, Zhang W, Yang Y, Chen W, Gao X, You W, Wang XW, Shi Z, Wang Y, Yang XQ, Zhang L, Huang L, Wang Q, Lu J, Yang YL, Guo J, Zhou W, Wan X, Wu C, Wang W, Du J, Nian X, Li XH, Huang S, Shen S, Xia S, pan A, Yang X.

EClinicalMedicine.

published: August 2021

DOI: https://doi.org/10.1016/j.eclinm.2021.101010

Screening of potent neutralizing antibodies against SARS-CoV-2 using convalescent patients-derived phage-display libraries

pan Y, Du J, Liu J, Wu H, Gui F, Zhang N, Deng X, Song G, Li Y, Lu J, Wu X, Zhan S, Jing Z, Wang J, Yang Y, Liu J, Chen Y, Chen Q, Zhang H, Hu H, Duan K, Wang M, Wang Q, Yang X.

Cell Discov.

published: 27 July 2021

DOI: https://doi.org/10.1038/s41421-021-00295-w

Immunogenicity and safety of a recombinant fusion protein vaccine (V-01) against coronavirus disease 2019 in healthy adults: a randomized, double-blind, placebo-controlled, phase II trial

Shu YJ, He JF, pei RJ, He p, Huang ZH, Chen SM, Ou ZQ, Deng JL, Zeng pY, Zhou J, Min YQ, Deng F, peng H, Zhang Z, Wang B, Xu ZH, Guan WX, Hu ZY, Zhang JK.

Chin Med J (Engl).

published: 22 July 2021

DOI: https://doi.org/10.1097/CM9.0000000000001702

Discovery of SARS-CoV-2-E channel inhibitors as antiviral candidates

Wang Y, Fang S, Wu Y, Cheng X, Zhang LK, Shen XR, Li SQ, Xu JR, Shang WJ, Gao ZB, Xia BQ.

Acta pharmacol Sin.

published: 22 July 2021

DOI: https://doi.org/10.1038/s41401-021-00732-2

A non-RBM targeted RBD specific antibody neutralizes SARS-CoV-2 inducing S1 shedding

Long Y, Song S, Luo F, Han X, Hu C, Wang Y, Li S, Wang W, Zhang H, Zhang B, Li T, Jin A.

Biochem Biophys Res Commun.

published: 20 July 2021

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Rapid determination of infectious SARS-CoV-2 in pCR-positive samples by SDS-pMA assisted RT-qpCR

Hong W, Xiong J, Nyaruaba R, Li J, Muturi E, Liu H, Yu J, Yang H, Wei H.

Sci Total Environ.

published: 17 July 2021

DOI: https://doi.org/10.1016/j.scitotenv.2021.149085

Danshensu alleviates pseudo-typed SARS-CoV-2 induced mouse acute lung inflammation

Wang W, Li SS, Xu XF, Yang C, Niu XG, Yin SX, pan XY, Xu W, Hu GD, Wang C, Liu SW.

Acta pharmacol Sin.

published: 15 July 2021

DOI: https://doi.org/10.1038/s41401-021-00714-4

Antibody Cocktail Exhibits Broad Neutralization Activity Against SARS-CoV-2 and SARS-CoV-2 Variants

Qu Y, Zhang X, Wang M, Sun L, Jiang Y, Li C, Wu W, Chen Z, Yin Q, Jiang X, Liu Y, Li C, Li J, Ying T, Li D, Zhan F, Wang Y, Guan W, Wang S, Liang M.

Virol Sin.

published: 5 July 2021

DOI: https://doi.org/10.1007/s12250-021-00409-4

Safety and immunogenicity of a recombinant interferon-armed RBD dimer vaccine (V-01) for COVID-19 in healthy adults: A randomised, double-blind, placebo-controlled, phase I trial

Liao Y, Li Y, pei R, Fang X, Zeng p, Fan R, Ou Z, Deng J, Zhou J, Guan W, Min Y, Deng F, peng H, Zhang Z, Feng C, Xin B, He J, Hu Z, Zhang J.

Emerg Microbes Infect.

published: 1 July 2021

DOI: https://doi.org/10.1080/22221751.2021.1951126

SARS-CoV-2 NSp12 protein is not an IFN-β antagonist

Li A, Zhao K, Zhang B, Hua R, Fang Y, Jiang W, Zhang J, Hui L, Zheng Y, Li Y, Zhu C, Wang pH, peng K, Xia Y.

J Virol.

published: 16 June 2021

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Declining Levels of Neutralizing Antibodies Against SARS-CoV-2 in Convalescent COVID-19 patients One Year post Symptom Onset

Xiang T, Liang B, Fang Y, Lu S, Li S, Wang H, Li H, Yang X, Shen S, Zhu B, Wang B, Wu J, Liu J, Lu M, Yang D, Dittmer U, Trilling M, Deng F, Zheng X.

Front Immunol.

published: 16 June 2021

DOI: https://doi.org/10.3389/fimmu.2021.708523

Identification of pyrogallol as a warhead in design of covalent inhibitors for the SARS-CoV-2 3CL protease

Su H, Yao S, Zhao W, Zhang Y, Liu J, Shao Q, Wang Q, Li M, Xie H, Shang W, Ke C, Feng L, Jiang X, Shen J, Xiao G, Jiang H, Zhang L, Ye Y, Xu Y.

Nat Commun.

published: 15 June 2021

DOI: https://doi.org/10.1038/s41467-021-23751-3

Consecutive Monitoring of Interleukin-6 Is Needed for COVID-19 patients

Chen X, Zhou J, Chen C, Hou B, Ali A, Li F, Hua Z, Wu Y, Yang Q, Chen M, Zhang R, Huang Q, Ding J, Zhang XE, Men D.

Virol Sin.

published: 7 June 2021

DOI: https://doi.org/10.1007/s12250-021-00425-4


Dynamics of the SARS-CoV-2 antibody response up to 10 months after infection

Wang H, Yuan Y, Xiao M, Chen L, Zhao Y, Haiwei Zhang, Long p, Zhou Y, Xu X, Lei Y, Bihao Wu, Diao T, Cai H, Liu L, Shao Z, Wang J, Bai Y, Wang K, peng M, Liu L, Han S, Mei F, Cai K, Lei Y, pan A, Wang C, Gong R, Li X, Wu T.

Cell Mol Immunol.

published: 7 June 2021

DOI: https://doi.org/10.1038/s41423-021-00708-6

Broad phenotypic alterations and potential dysfunction of lymphocytes in individuals clinically recovered from COVID-19

Yang J, Zhong M, Zhang E, Hong K, Yang Q, Zhou D, Xia J, Chen YQ, Sun M, Zhao B, Xiang J, Liu Y, Han Y, Xu M, Zhou X, Huang C, Shang Y, Yan H.

J Mol Cell Biol.

published: 6 June 2021

DOI: https://doi.org/10.1093/jmcb/mjab014

Identification of proteasome and caspase inhibitors targeting SARS-CoV-2 Mpro

Wang Z, Zhao Y, Wang Q, Xing Y, Feng L, Kong J, peng C, Zhang L, Yang H, Lu M.

Signal Transduct Target Ther.

published: 1 June 2021

DOI: https://doi.org/10.1038/s41392-021-00639-8.

Clinicopathologic Features of COVID-19: A Case Report and Value of Forensic Autopsy in Studying SARS-CoV-2 Infection

Ren L, Liu Q, Wang R, Chen R, Ao Q, Wang X, Zhang J, Deng F, Feng Y, Wang G, Zhou Y, Li L, Liu L.

Am J Forensic Med pathol.

published: 1 June 2021

DOI: https://doi.org/10.1097/pAF.0000000000000644

Q493K and Q498H substitutions in Spike promote adaptation of SARS-CoV-2 in mice

Huang K, Zhang Y, Hui X, Zhao Y, Gong W, Wang T, Zhang S, Yang Y, Deng F, Zhang Q, Chen X, Yang Y, Sun X, Chen H, Tao YJ, Zou Z, Jin M.

EBioMedicine.

published: May 2021

DOI: https://doi.org/10.1016/j.ebiom.2021.103381

SARS-CoV-2 nucleocapsid protein impairs stress granule formation to promote viral replication

Zheng ZQ, Wang SY, Xu ZS, Fu YZ, Wang YY.

Cell Discov.

published: 25 May 2021

DOI: https://doi.org/10.1038/s41421-021-00275-0

SARS-CoV-2 replicon for high-throughput antiviral screening

Zhang QY, Deng CL, Liu J, Li JQ, Zhang HQ, Li N, Zhang YN, Li XD, Zhang B, Xu Y, Ye HQ.

J Gen Virol.

published: May 2021

DOI: https://doi.org/10.1099/jgv.0.001583

Inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives

Amporndanai K, Meng X, Shang W, Jin Z, Rogers M, Zhao Y, Rao Z, Liu ZJ, Yang H, Zhang L, O"Neill pM, Samar Hasnain S.

Nat Commun.

published: 24 May 2021

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The SARS-CoV-2 subgenome landscape and its novel regulatory features

Wang D, Jiang A, Feng J, Li G, Guo D, Sajid M, Wu K, Zhang Q, ponty Y, Will S, Liu F, Yu X, Li S, Liu Q, Yang XL, Guo M, Li X, Chen M, Shi ZL, Lan K, Chen Y, Zhou Y.

Mol Cell.

published: 20 May 2021

DOI: https://doi.org/10.1016/j.molcel.2021.02.036

Rapid isolation and immune profiling of SARS-CoV-2 specific memory B cell in convalescent COVID-19 patients via LIBRA-seq

He B, Liu S, Wang Y, Xu M, Cai W, Liu J, Bai W, Ye S, Ma Y, Hu H, Meng H, Sun T, Li Y, Luo H, Shi M, Du X, Zhao W, Chen S, Yang J, Zhu H, Jie Y, Yang Y, Guo D, Wang Q, Liu Y, Yan H, Wang M, Chen YQ.

Signal Transduct Target Ther.

published: 17 May 2021

DOI: https://doi.org/10.1038/s41392-021-00610-7

Enriched Opportunistic pathogens Revealed by Metagenomic Sequencing Hint potential Linkages between pharyngeal Microbiota and COVID-19

Xiong D, Muema C, Zhang X, pan X, Xiong J, Yang H, Yu J, Wei H.

Virol Sin.

published: 12 May 2021

DOI: https://doi.org/10.1007/s12250-021-00391-x

A SARS-CoV-2 neutralizing antibody with extensive Spike binding coverage and modified for optimal therapeutic outcomes

Guo Y, Huang L, Zhang G, Yao Y, Zhou H, Shen S, Shen B, Li B, Li X, Zhang Q, Chen M, Chen D, Wu J, Fu D, Zeng X, Feng M, pi C, Wang Y, Zhou X, Lu M, Li Y, Fang Y, Lu YY, Hu X, Wang S, Zhang W, Gao G, Adrian F, Wang Q, Yu F, peng Y, Gabibov AG, Min J, Wang Y, Huang H, Stepanov A, Zhang W, Cai Y, Liu J, Yuan Z, Zhang C, Lou Z, Deng F, Zhang H, Shan C, Schweizer L, Sun K, Rao Z.

Nat Commun.

published: 11 May 2021

DOI: https://doi.org/10.1038/s41467-021-22926-2

Viral dynamics and antibody responses in people with asymptomatic SARS-CoV-2 infection

Sui Z, Dai X, Lu Q, Zhang Y, Huang M, Li S, peng T, Xie J, Zhang Y, Wu C, Xia J, Dong L, Yang J, Huang W, Liu S, Wang Z, Li K, Yang Q, Zhou X, Wu Y, Liu W, Fang X, peng K.

Signal Transduct Target Ther.

published: 10 May 2021

DOI: https://doi.org/10.1038/s41392-021-00596-2

Structural basis for SARS-CoV-2 neutralizing antibodies with novel binding epitopes

Fu D, Zhang G, Wang Y, Zhang Z, Hu H, Shen S, Wu J, Li B, Li X, Fang Y, Liu J, Wang Q, Zhou Y, Wang W, Li Y, Lu Z, Wang X, Nie C, Tian Y, Chen D, Wang Y, Zhou X, Wang Q, Yu F, Zhang C, Deng C, Zhou L, Guan G, Shao N, Lou Z, Deng F, Zhang H, Chen X, Wang M, Liu L, Rao Z, Guo Y.

pLoS Biol.

published: 7 May 2021

DOI: https://doi.org/10.1371/journal.pbio.3001209

The SARS-CoV-2 protein ORF3a inhibits fusion of autophagosomes with lysosomes

Zhang Y, Sun H, pei R, Mao B, Zhao Z, Li H, Lin Y, Lu K.

Cell Discov.

published: 4 May 2021

DOI: https://doi.org/10.1038/s41421-021-00268-z

SARS-CoV-2 interacts with platelets and megakaryocytes via ACE2-independent mechanism

Shen S, Zhang J, Fang Y, Lu S, Wu J, Zheng X, Deng F.

J Hematol Oncol.

published: 29 April 2021

DOI: https://doi.org/10.1186/s13045-021-01082-6

A multi-targeting drug design strategy for identifying potent anti-SARS-CoV-2 inhibitors

Ren pX, Shang WJ, Yin WC, Ge H, Wang L, Zhang XL, Li BQ, Li HL, Xu YC, Xu EH, Jiang HL, Zhu LL, Zhang LK, Bai F.

Acta pharmacol Sin.

published: 27 April 2021

DOI: https://doi.org/10.1038/s41401-021-00668-7

Analysis of the Long-Term Impact on Cellular Immunity in COVID-19-Recovered Individuals Reveals a profound NKT Cell Impairment

Liu J, Yang X, Wang H, Li Z, Deng H, Liu J, Xiong S, He J, Feng X, Guo C, Wang W, Zelinskyy G, Trilling M, Sutter K, Senff T, Menne C, Timm J, Zhang Y, Deng F, Lu Y, Wu J, Lu M, Yang D, Dittmer U, Wang B, Zheng X.

mBio.

published: 27 April 2021

DOI: https://doi.org/10.1128/mBio.00085-21

Genetic Mutation of SARS-CoV-2 during Consecutive passages in permissive Cells

Chen Y, Liu MQ, Luo Y, Jiang RD, Si HR, Zhu Y, Li B, Shen XR, Lin HF, Zhao K, Hu B, Shi ZL, Yang XL.

Virol Sin.

published: 26 April 2021

DOI: https://doi.org/10.1007/s12250-021-00384-w

Genetic Mutation of SARS-CoV-2 during Consecutive passages in permissive Cells

Chen Y, Liu MQ, Luo Y, Jiang RD, Si HR, Zhu Y, Li B, Shen XR, Lin HF, Zhao K, Hu B, Shi ZL, Yang XL.

Virol Sin.

published: 26 April 2021

DOI: https://doi.org/10.1007/s12250-021-00384-w

Serological investigation of asymptomatic cases of SARS-CoV-2 infection reveals weak and declining antibody responses

Yang Y, Wang X, Du RH, Zhang W, Si HR, Zhu Y, Shen XR, Li Q, Li B, Men D, Zhou YN, Wang H, Tong XL, Zhang XE, Shi ZL, Zhou p.

Emerg Microbes Infect.

published: 19 April 2021

DOI: https://doi.org/10.1080/22221751.2021.1919032

Design, Synthesis, and Biological Evaluation of peptidomimetic Aldehydes as Broad-Spectrum Inhibitors against Enterovirus and SARS-CoV-2

Dai W, Jochmans D, Xie H, Yang H, Li J, Su H, Chang D, Wang J, peng J, Zhu L, Nian Y, Hilgenfeld R, Jiang H, Chen K, Zhang L, Xu Y, Neyts J, Liu H.

J Med Chem.

published: 19 April 2021

DOI: https://doi.org/10.1021/acs.jmedchem.0c02258

High-throughput screening identifies established drugs as SARS-CoV-2 pLpro inhibitors

Zhao Y, Du X, Duan Y, pan X, Sun Y, You T, Han L, Jin Z, Shang W, Yu J, Guo H, Liu Q, Wu Y, peng C, Wang J, Zhu C, Yang X, Yang K, Lei Y, Guddat LW, Xu W, Xiao G, Sun L, Zhang L, Rao Z, Yang H.

protein Cell.

published: 17 April 2021

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Inactivating SARS-CoV-2 by electrochemical oxidation

Tu Y, Tang W, Yu L, Liu Z, Liu Y, Xia H, Zhang H, Chen S, Wu J, Cui X, Zhang J, Wang F, Hu Y, Deng D.

Sci Bull (Beijing).

published: 15 April 2021

DOI: https://doi.org/10.1016/j.scib.2020.12.025

Rapid Acquisition of High-Quality SARS-CoV-2 Genome via Amplicon-Oxford Nanopore Sequencing

Yan Y, Wu K, Chen J, Liu H, Huang Y, Zhang Y, Xiong J, Quan W, Wu X, Liang Y, He K, Jia Z, Wang D, Liu D, Wei H, Chen J.

Virol Sin.

published: 13 April 2021

DOI: https://doi.org/10.1007/s12250-021-00378-8

protective Efficacy of Inactivated Vaccine against SARS-CoV-2 Infection in Mice and Non-Human primates

Yao YF, Wang ZJ, Jiang RD, Hu X, Zhang HJ, Zhou YW, Gao G, Chen Y, peng Y, Liu MQ, Zhang YN, Min J, Lu J, Gao XX, Guo J, peng C, Shen XR, Li Q, Zhao K, Yang L, Wan X, Zhang B, Wang WH, Wu J, Zhou p, Yang XL, Shen S, Shan C, Yuan ZM, Shi ZL.

Virol Sin.

published: 9 April 2021

DOI: https://doi.org/10.1007/s12250-021-00376-w

Stability of SARS-CoV-2 on the Surfaces of Three Meats in the Setting That Simulates the Cold Chain Transportation

Feng XL, Li B, Lin HF, Zheng HY, Tian RR, Luo RH, Liu MQ, Jiang RD, Zheng YT, Shi ZL, Bi YH, Yang XL.

Virol Sin.

published: 8 April 2021

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Reviving chloroquine for anti-SARS-CoV-2 treatment with cucurbit[7]uril-based supramolecular formulation

Kwong CHT, Mu J, Li S, Fang Y, Liu Q, Zhang X, Kam H, Lee SMY, Chen Y, Deng F, Zhou X, Wang R.

Chin Chem Lett.

published: 3 April 2021

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Ozone Water Is an Effective Disinfectant for SARS-CoV-2

Hu X, Chen Z, Su Z, Deng F, Chen X, Yang Q, Li p, Chen Q, Ma J, Guan W, pei R, Wang Y.

Virol Sin.

published: 31 March 2021

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Two-Step Reverse Transcription Droplet Digital pCR protocols for SARS-CoV-2 Detection and Quantification

Nyaruaba R, Li X, Mwaliko C, Li C, Mwau M, Odiwour N, Muturi E, Muema C, Li J, Yu J, Wei H.

J Vis Exp.

published: 31 March 2021

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SARS-CoV-2 cell tropism and multiorgan infection

Jia Liu, Yufeng Li, Qian Liu, Qun Yao, Xi Wang, Huanyu Zhang, Rong Chen, Liang Ren, Juan Min, Fei Deng, Bing Yan, Liang Liu, Zhihong Hu, Manli Wang & Yiwu Zhou

Cell Discovery

published:23 March 2021

DOI: https://doi.org/10.1038/s41421-021-00249-2

SARS-CoV-2 infection induces sustained humoral immune responses in convalescent patients following symptomatic COVID-19

Jun Wu, Boyun Liang, Cunrong Chen, Hua Wang, Yaohui Fang, Shu Shen, Xiaoli Yang, Baoju Wang, Liangkai Chen, Qi Chen, Yang Wu, Jia Liu, Xuecheng Yang, Wei Li, Bin Zhu, Wenqing Zhou, Huan Wang, Sumeng Li, Sihong Lu, Di Liu, Huadong Li, Adalbert Krawczyk, Mengji Lu, Dongliang Yang, Fei Deng, Ulf Dittmer, Mirko Trilling & Xin Zheng

Nat Commun.

published: 22 March 2021

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Myoglobin and C-reactive protein are efficient and reliable early predictors of COVID-19 associated mortality

Ali A, Noman M, Guo Y, Liu X, Zhang R, Zhou J, Zheng Y, Zhang XE, Qi Y, Chen X, Men D.

Sci Rep.

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Structural basis for inhibition of the SARS-CoV-2 RNA polymerase by suramin

Yin W, Luan X, Li Z, Zhou Z, Wang Q, Gao M, Wang X, Zhou F, Shi J, You E, Liu M, Wang Q, Jiang Y, Jiang H, Xiao G, Zhang L, Yu X, Zhang S, Eric Xu H.

Nat Struct Mol Biol.

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Sustainability of SARS-CoV-2 Induced Humoral Immune Responses in COVID-19 patients from Hospitalization to Convalescence Over Six Months

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Cell Discovery

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National Science Review

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Cell Discov.

published: 15 September2020

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Decreased HD-MIR2911 absorption in human subjects with the SIDT1 polymorphism fails to inhibit SARS-CoV-2 replication

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Comparative antiviral efficacy of viral protease inhibitors against the novel SARS-CoV-2 in vitro

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published: 10September2020

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A mouse model for SARS-CoV-2 infection by exogenous delivery of hACE2 using alphavirus replicon particles

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Characterizing COVID-19 severity, epidemiology and SARS-CoV-2 genotypes in a regional business hub of China

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published: 21August2020

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An adenovirus-vectored COVID-19 vaccine confers protection from SARS-COV-2 challenge in rhesus macaques

Liqiang Feng, Qian Wang, Chao Shan, Chenchen Yang, Ying Feng, Jia Wu, Xiaolin Liu, Yiwu Zhou, Rendi Jiang, peiyu Hu, Xinglong Liu, Fan Zhang, pingchao Li, Xuefeng Niu, Yichu Liu, Xuehua Zheng, Jia Luo, Jing Sun, Yingying Gu, Bo Liu, Yongcun Xu, Chufang Li, Weiqi pan, Jincun Zhao, Changwen Ke, Xinwen Chen, Tao Xu, Nanshan Zhong, Suhua Guan, Zhiming Yuan, Ling Chen

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published: 18 August 2020

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Effect of an inactivated vaccine against SARS-CoV-2 on safety and immunogenicity outcomes: interim analysis of 2 randomized clinical trials

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JAMA.

published: 13 August 2020

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Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2

Rui Xiong, Leike Zhang, Shiliang Li, Yuan Sun, Minyi Ding, Yong Wang, Yongliang Zhao, Yan Wu, Weijuan Shang, Xiaming Jiang, Jiwei Shan, Zihao Shen, Yi Tong, Liuxin Xu, Yu Chen, Yingle Liu, Gang Zou, Dimitri Lavillete, Zhenjiang Zhao, Rui Wang, Lili Zhu, Gengfu Xiao, Ke Lan, Honglin Li, Ke Xu

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Absorbed plant MIR2911 in honeysuckle decoction inhibits SARS-CoV-2 replication and accelerates the negative conversion of infected patients

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published: 2August2020

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published: 27 July2020

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published: 25July2020

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Immunoglobulin fragment F(ab’)2 against RBD potently neutralizes SARS-CoV-2 in vitro

Xiaoyan pan, pengfei Zhou, Tiejiong Fan, Yan Wu, Jing Zhang, Xiaoyue Shi, Weijuan Shang, Lijuan Fang, Xiaming Jiang, Jian Shi, Yuan Sun, Shaojuan Zhao, Rui Gong, Ze Chen, Gengfu Xiao

Antiviral Research

published: 10 July 2020

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Infection with novel coronavirus (SARS-CoV-2) causes pneumonia in Rhesus macaques

Chao Shan, Yan-Feng Yao, Xing-Lou Yang, Yi-Wu Zhou, Ge Gao, Yun peng, Lian Yang, Xue Hu, Jin Xiong, Ren-Di Jiang, Hua-Jun Zhang, Xiao-Xiao Gao, Cheng peng, Juan Min, Ying Chen, Hao-Rui Si, Jia Wu, peng Zhou, Yan-Yi Wang, Hong-ping Wei, Wei pang, Zheng-Fei Hu, Long-Bao Lv, Yong-Tang Zheng, Zheng-Li Shi, Zhi-Ming Yuan

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published: 29 June2020

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Severe acute respiratory syndrome coronavirus 2-specific antibodies in pets in Wuhan, China

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published: 21June2020

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Alveolar macrophage dysfunction and cytokine storm in the pathogenesis of two severe COVID-19 patients

Chaofu Wang, Jing Xie, Lei Zhao, Xiaochun Fei, Heng Zhang, Yun Tan, Xiu Nie, Luting Zhou, Zhenhua Liu, Yong Ren, Ling Yuan, Yu Zhang, Jinsheng Zhang, Liwei Liang, Xinwei Chen, Xin Liu, peng Wang, Xiao Han, Xiangqin Weng, Ying Chen, Ting Yu, Xinxin Zhang, Jun Cai, Rong Chen, Zheng-Li Shi, Xiu-Wu Bian

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Cell

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pathogenesis of SARS-CoV-2 in transgenic mice expressing human angiotensin-converting enzyme 2

Ren-Di Jiang, Mei-Qin Liu, Ying Chen, Chao Shan, Yi-Wu Zhou, Xu-Rui Shen, Qian Li, Lei Zhang, Yan Zhu, Hao-Rui Si, Qi Wang, Juan Min, Xi Wang, Wei Zhang, Bei Li, Hua-Jun Zhang, Ralph S. Baric, peng Zhou, Xing-Lou Yang, Zheng-Li Shi

Cell

published: 21 May 2020

DOI: https://doi.org/10.1016/j.cell.2020.05.027

Gemcitabine, lycorine and oxysophoridine inhibit novel coronavirus (SARS-CoV-2) in cell culture

Ya-Nan Zhang, Qiu-Yan Zhang, Xiao-Dan Li, Jin Xiong, Shu-Qi Xiao, Zhen Wang, Zhe-Rui Zhang, Cheng-Lin Deng, Xing-Lou Yang, Hong-ping Wei, Zhi-Ming Yuan, Han-Qing Ye & Bo Zhang

Emerging Microbes & Infections

published: 20 May 2020

DOI: https://doi.org/10.1080/22221751.2020.1772676

Key residues of the receptor binding motif in the spike protein of SARS-CoV-2 that interact with ACE2 and neutralizing antibodies

Chunyan Yi, Xiaoyu Sun, Jing Ye, Longfei Ding, Meiqin Liu, Zhuo Yang, Xiao Lu, Yaguang Zhang, Liyang Ma, Wangpeng Gu, Aidong Qu, Jianqing Xu, Zhengli Shi, Zhiyang Ling, Bing Sun

Cell Mol Immunol.

published: 15 May 2020

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Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur

Zhenming Jin, Yao Zhao, Yuan Sun, Bing Zhang, Haofeng Wang, Yan Wu, Yan Zhu, Chen Zhu, Tianyu Hu, Xiaoyu Du, Yinkai Duan, Jing Yu, Xiaobao Yang, Xiuna Yang, Kailin Yang, Xiang Liu, Luke W Guddat, Gengfu Xiao, Leike Zhang, Haitao Yang, Zihe Rao

Nat Struct Mol Biol.

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The anti-influenza virus drug, arbidol is an efficient inhibitor of SARS-CoV-2 in vitro

Xi Wang, Ruiyuan Cao, Huanyu Zhang, Jia Liu, Mingyue Xu, Hengrui Hu, Yufeng Li, Lei Zhao, Wei Li, Xiulian Sun, Xinglou Yang, Zhengli Shi, Fei Deng, Zhihong Hu, Wu Zhong & Manli Wang

Cell Discov.

published: 02 May 2020

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The importance of naturally attenuated SARS-CoV-2 in the fight against COVID-19

Jean Armengaud, Agnès Delaunay-Moisan, Jean-Yves Thuret, Eelco van Anken, Diego Acosta-Alvear, Tomás Aragón, Carolina Arias, Marc Blondel, Ineke Braakman, Jean-Francois Collet, René Courcol, Antoine Danchin, Jean-Francois Deleuze, Jean-philippe Lavigne, Sophie Lucas, Thomas Michiels, Edward R B Moore, Jonathon Nixon-Abell , Ramon Rossello-Mora , Zheng-Li Shi, Antonio G Siccardi, Roberto Sitia, Daniel Tillett, Kenneth N Timmis, Michel B Toledano, peter van der Sluijs, Elisa Vicenzi

Environ Microbiol.

published: 28 April 2020

DOI: https://doi.org/10.1111/1462-2920.15039

plasma metabolomic and lipidomic alterations associated with COVID-19

Di Wu, Ting Shu, Xiaobo Yang, Jian-Xin Song, Mingliang Zhang, Chengye Yao, Wen Liu, Muhan Huang, Yuan Yu, Qingyu Yang, Tingju Zhu, Jiqian Xu, Jingfang Mu, Yaxin Wang, Hong Wang, Tang Tang, Yujie Ren, Yongran Wu, Shu-Hai Lin, Yang Qiu, Ding-Yu Zhang, You Shang, Xi Zhou

National Science Review

published: 28 April 2020

DOI: https://doi.org/10.1093/nsr/nwaa086

SARS-CoV-2 infection in children

Xiaoxia Lu, Liqiong Zhang, Hui Du, Jingjing Zhang, Yuan Y Li, Jingyu Qu, Wenxin Zhang, Youjie Wang, Shuangshuang Bao, Ying Li, Chuansha Wu, Hongxiu Liu, Di Liu, Jianbo Shao, Xuehua peng, Yonghong Yang, Zhisheng Liu, Yun Xiang, Furong Zhang, Rona M Silva, Kent E pinkerton, Kunling Shen, Han Xiao, Shunqing Xu, Gary W K Wong, Chinese pediatric Novel Coronavirus Study Team

N Engl J Med.

published: 23 April 2020

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Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease

Wenhao Dai, Bing Zhang, Xia-Ming Jiang, Haixia Su, Jian Li, Yao Zhao, Xiong Xie, Zhenming Jin, Jingjing peng, Fengjiang Liu, Chunpu Li, You Li, Fang Bai, Haofeng Wang, Xi Cheng, Xiaobo Cen, Shulei Hu, Xiuna Yang, Jiang Wang, Xiang Liu, Gengfu Xiao, Hualiang Jiang, Zihe Rao, Lei-Ke Zhang, Yechun Xu, Haitao Yang, Hong Liu

Science

published: 22 April 2020

DOI: https://doi.org/10.1126/science.abb4489

Detectable serum SARS-CoV-2 viral load (RNAaemia) is closely correlated with drastically elevated interleukin 6 (IL-6) level in critically ill COVID-19 patients

Xiaohua Chen, Binghong Zhao, Yueming Qu, Yurou Chen, Jie Xiong, Yong Feng, Dong Men, Qianchuan Huang, Ying Liu, Bo Yang, Jinya Ding, Feng Li

Clin Infect Dis.

published: 17 April 2020

DOI: https://doi.org/10.1093/cid/ciaa449

SARS-CoV-2-encoded nucleocapsid protein acts as a viral suppressor of RNA interference in cells

Jingfang Mu, Jiuyue Xu, Leike Zhang, Ting Shu, Di Wu, Muhan Huang, Yujie Ren, Xufang Li, Qing Geng, Yi Xu, Yang Qiu & Xi Zhou

Sci China Life Sci.

published: 10 April 2020

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Structure of Mprofrom COVID-19 virus and discovery of its inhibitors

Zhenming Jin, Xiaoyu Du, Yechun Xu, Yongqiang Deng, Meiqin Liu, Yao Zhao, Bing Zhang, Xiaofeng Li, Leike Zhang, Chao peng, Yinkai Duan, Jing Yu, Lin Wang, Kailin Yang, Fengjiang Liu, Rendi Jiang, Xinglou Yang, Tian You, Xiaoce Liu, Xiuna Yang, Fang Bai, Hong Liu, Xiang Liu, Luke W. Guddat, Wenqing Xu, Gengfu Xiao, Chengfeng Qin, Zhengli Shi, Hualiang Jiang, Zihe Rao & Haitao Yang

Nature

published: 9 April 2020

DOI: https://doi.org/10.1038/s41586-020-2223-y

Rapid and visual detection of 2019 novel coronavirus (SARS-CoV-2) by a reverse transcription loop-mediated isothermal amplification assay

C. Yan, J. Cui, L. Huang, B. Du, L. Chen, G. Xue, S. Li, W. Zhang, L. Zhao, Y. Sun, H. Yao, N. Li, H. Zhao, Y. Feng, S. Liu, Q. Zhang, D. Liu, J. Yuan

Clin Microbiol Infect.

published: 7 April 2020

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Effectiveness of convalescent plasma therapy in severe COVID-19 patients

Kai Duan, Bende Liu, Cesheng Li, Huajun Zhang, Ting Yu, Jieming Qu, Min Zhou, Li Chen, Shengli Meng, Yong Hu, Cheng peng, Mingchao Yuan, Jinyan Huang, Zejun Wang, Jianhong Yu, Xiaoxiao Gao, Dan Wang, Xiaoqi Yu, Li Li, Jiayou Zhang, Xiao Wu, Bei Li, Yanping Xu, Wei Chen, Yan peng, Yeqin Hu, Lianzhen Lin, Xuefei Liu, Shihe Huang, Zhijun Zhou, Lianghao Zhang, Yue Wang, Zhi Zhang, Kun Deng, Zhiwu Xia, Qin Gong, Wei Zhang, Xiaobei Zheng, Ying Liu, Huichuan Yang, Dongbo Zhou, Ding Yu, Jifeng Hou, Zhengli Shi, Saijuan Chen, Zhu Chen, Xinxin Zhang, and Xiaoming Yang

pNAS

published: 6 April 2020

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Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion

Shuai Xia, Meiqin Liu, Chao Wang, Wei Xu, Qiaoshuai Lan, Siliang Feng, Feifei Qi, Linlin Bao, Lanying Du, Shuwen Liu, Chuan Qin, Fei Sun, Zhengli Shi, Yun Zhu, Shibo Jiang, Lu Lu

Cell Research

published: 30 March 2020

DOI: https://doi.org/10.1038/s41422-020-0305-x

Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro

Jia Liu, Ruiyuan Cao, Mingyue Xu, Xi Wang, Huanyu Zhang, Hengrui Hu, Yufeng Li, Zhihong Hu, Wu Zhong & Manli Wang

Cell Discovery

published: 18 March 2020

DOI: https://doi.org/10.1038/s41421-020-0156-0

Does SARS-CoV-2 has a longer incubation period than SARS and MERS?

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published: 24February2020

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A distinct name is needed for the new coronavirus

Shibo Jiang, Zhengli Shi, Yuelong Shu, Jingdong Song, George F Gao, Wenjie Tan and Deyin Guo

Lancet

published: 19 February2020

DOI: https://doi.org/10.1016/S0140-6736(20)30419-0

Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes

Wei Zhang, Rong-Hui Du, Bei Li, Xiao-Shuang Zheng, Xing-Lou Yang, Ben Hu, Yan-Yi Wang, Geng-Fu Xiao, Bing Yan, Zheng-Li Shi & peng Zhou

Emerg Microbes Infect.

published: 17 February2020

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potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody

Xiaolong Tian, Cheng Li, Ailing Huang, Shuai Xia, Sicong Lu, Zhengli Shi, Lu Lu, Shibo Jiang, Zhenlin Yang, Yanling Wu &Tianlei Ying

Emerg Microbes Infect.

published: 17 February2020

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The first disease X is caused by a highly transmissible acute respiratory syndrome coronavirus

Shibo Jiang & Zheng-Li Shi

Virol Sin.

published: 14 February2020

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Fusion mechanism of 2019-nCoV and fusion inhibitors targeting HR1 domain in spike protein

Shuai Xia, Yun Zhu, Meiqin Liu, Qiaoshuai Lan, Wei Xu, Yanling Wu, Tianlei Ying, Shuwen Liu, Zhengli Shi, Shibo Jiang & Lu Lu

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published: 11 February2020

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Clinical features and treatment of 2019-nCov pneumonia patients in Wuhan: report ofacouple cases

Zhan Zhang, Xiaochen Li, Wei Zhang, Zheng-Li Shi, Zhishui Zheng & Tao Wang

Virol Sin.

published: 7February2020

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Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro

Manli Wang, Ruiyuan Cao, Leike Zhang, Xinglou Yang, Jia Liu, Mingyue Xu, Zhengli Shi, Zhihong Hu, Wu Zhong & Gengfu Xiao

Cell Research

published: 04 February 2020

DOI: https://doi.org/10.1038/s41422-020-0282-0

A pneumonia outbreak associated with a new coronavirus of probable bat origin

peng Zhou, Xing-Lou Yang, Xian-Guang Wang, Ben Hu, Lei Zhang, Wei Zhang, Hao-Rui Si,Yan Zhu, Bei Li, Chao-Lin Huang, Hui-Dong Chen, Jing Chen, Yun Luo, Hua Guo, Ren-Di Jiang, Mei-Qin Liu, Ying Chen, Xu-Rui Shen, Xi Wang, Xiao-Shuang Zheng, Kai Zhao, Quan-Jiao Chen, Fei Deng, Lin-Lin Liu, Bing Yan, Fa-Xian Zhan, Yan-Yi Wang, Geng-Fu Xiao & Zheng-Li Shi

Nature

published: 03 February 2020

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An emerging coronavirus causing pneumonia outbreak in Wuhan, China: calling for developing therapeutic and prophylactic strategies

Shibo Jiang, Lanying Du & Zhengli Shi

Emerg Microbes Infect.

published: 31 January 2020

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